Alli (Orlistat) 60mg — Weight Loss Capsules pricing
Transparent and competitive pricing plans designed to help you manage your weight loss journey effectively.
What is Alli (Orlistat)?
Alli (orlistat 60mg) is an MHRA-approved weight loss capsule manufactured by Haleon (formerly GSK). It is a pancreatic lipase inhibitor — a medicine that works directly inside the gut to reduce the amount of dietary fat your body absorbs from food.
Unlike appetite suppressants or stimulants, Alli does not act on the brain or central nervous system. It works locally in the digestive tract, making it one of the most mechanically straightforward weight loss treatments available without a prescription in the UK.
Alli belongs to the same drug class as prescription Xenical (orlistat 120mg) but is available over the counter because the 60mg dose carries a well-characterised safety profile suitable for self-directed use under pharmacist guidance.
Both Alli and alternative Orlos contain the same active ingredient at the same dose; the key differences between them are manufacturer and retail price rather than clinical effect.
Set off on the right foot with weight loss medication that’s proven to help you hit the ground running and reach your goals faster.
GLP-1 medications reduce cravings by directly influencing the brain's reward centre, reducing the urge to reach for unhealthy snacks.
GLP-1 medications help to lower the body's natural weight ‘set point’, so weight can continue to be lost without hitting a plateau.
By improving insulin sensitivity, GLP-1 medications can help manage weight for everyone - even those with slower metabolic rates.
Thousands of people in the UK trust Bliss
Jamie
Lost 14 stone in 18 months“That achievement sparked something in me. It made me realise how much I enjoy fitness and helping others.”
Melissa
Lost 25 pounds in 3 months“The support they provided, combined with healthier lifestyle choices, helped me achieve results that I had struggled to reach on my own.”
Glenn
Lost 3.3 stone in 3 months“While I still have goals to achieve, I’m moving in the right direction and feel more hopeful than I did before I started.”
How much weight could you lose?
Clinical trials for prescription weight loss medication show significant, sustained results for eligible adults. On average, patients in published studies lost between 14% and 21% of their body weight over 12 to 18 months — that's the equivalent of 12–18kg for someone who weighs 85kg.
Your individual results will depend on your starting weight, the treatment your clinician recommends, and how closely you follow your programme. Use the calculator below to see an estimate based on your details.
BMI is a predictive indicator of weight range. For a more in-depth understanding of your weight and available medical solutions, start an online consultation with a bliss doctor today.
A specialist team
Our programme is created by experts in the biology and psychology of weight loss
Julia Keller
Head of Behavioural Change
Umar Razzaq
Founder & Superintendent Pharmacist
Nish Fayyaz
Pharmacist
Sohail Din
Pharmacist Prescriber
Frequently asked questions
Does Alli work for weight loss?
Yes — in clinical studies, more than 40% of people taking Alli alongside a calorie-controlled, low-fat diet lost at least 5% of their body weight [1, 2].
Alli is not a magic solution, and results depend heavily on dietary compliance, but it is a clinically validated aid for weight management in adults with a BMI of 28 or above.How long does Alli take to work?
Alli begins blocking fat absorption from the first capsule. Early weight loss (within the first month) is typically modest — most people notice more meaningful progress over 3–6 months as the consistent calorie deficit from reduced fat absorption accumulates. Continued use alongside a low-fat diet gives the best long-term results.
Can I buy Alli without a prescription?
Yes. Alli (orlistat 60mg) is available over the counter in the UK without a prescription for adults with a BMI of 28 or above. At Bliss, your clinician will carry out an eligibility check before your order is processed to ensure Alli is appropriate and safe for you.
What is the difference between Alli and Xenical?
Alli contains orlistat 60mg and is available over the counter for adults with a BMI of 28+. Xenical contains orlistat 120mg — double the OTC dose — and is prescription-only, generally prescribed for adults with a BMI of 30 or above (or 28+ with weight-related health conditions).
Xenical blocks approximately 30% of dietary fat compared to approximately 25% with Alli. Both products work via the same mechanism; the prescription dose is stronger and requires clinician oversight.What is the difference between Alli and Orlos?
Alli and Orlos both contain orlistat 60mg and work identically. The difference is brand and manufacturer: Alli is made by Haleon and is typically priced at a premium, while Orlos is made by Ethical Naturals Ltd and is usually available at a lower cost. If budget is a consideration and you are comfortable with a generic brand, Orlos and Alli are clinically interchangeable.
Is Alli safe for long-term use?
Orlistat has been used clinically since 1998 and has a well-characterised long-term safety profile [2]. OTC use of Alli should not exceed six months — and if you haven't lost at least 5% of initial body weight within 12 weeks, it's worth speaking to your pharmacist or doctor to review your plan [2] .
At Bliss, that conversation is built into your programme. Your dedicated clinician monitors your progress throughout, so whether Alli needs adjusting or you want to explore your options beyond six months, you'll have the right medical guidance at every step.Should I take Alli or Mounjaro?
This depends on your BMI, health history, and weight loss goals. Alli is appropriate for adults with a BMI of 28+ who want an OTC, capsule-based option. Mounjaro (tirzepatide) is a weekly injection prescribed for adults with a BMI of 30+ (or 27+ with weight-related conditions) and produces greater average weight loss. Our clinicians can help you assess which option is right for you based on your individual profile.
Real people, real impact
Your Weight Loss Timeline
See what could be possible in just 12 months with Bliss. A year of expert-led support, a lifetime of healthier habits.
Kickstart your journey
Complete a short online health assessment — it takes around five minutes. A UK-registered Bliss clinician reviews your answers, confirms your eligibility and recommends a weight loss treatment plan tailored to your BMI and health profile. Your first prescription is dispensed by our GPhC-registered pharmacy and delivered directly to your door.
Healthy, sustainable weight loss
Your treatment dose increases gradually — this is intentional. It gives your body time to adjust and helps minimise side effects. Most Bliss members begin to see consistent, measurable weight loss within 4–8 weeks. Your Bliss dietitian keeps your nutrition on track throughout, ensuring your weight loss is fat loss — not muscle.
Long-term results
For eligible members, the goal is sustained, clinically meaningful weight loss — typically 10–20% of body weight over 12 months. Unlike fad diets, a medically supervised weight loss programme is designed to produce results that last. Ongoing Bliss support ensures your progress is maintained, not reversed.