Weight Loss Injections UK — Clinician-Prescribed by Bliss
With the latest weight loss injections, doctor led support and nutrition coaching, our tailored solutions are designed to support you on your journey towards a healthier happier you.
- Clinically proven GLP-1 medical treatments
- 21% average reduction in body weight within one year¹
How do weight loss injections work?
GLP-1 weight loss injections mimic a hormone your gut naturally releases after eating, slowing digestion, reducing hunger signals, and increasing fullness — without relying on willpower. Mounjaro goes further by activating a second hormone receptor (GIP), producing greater average weight loss than any other licensed injection in the UK.
Mimics GLP-1 — a hormone your gut naturally releases after eating — to reduce hunger signals between meals and slow the rate at which your stomach empties.
Activates GLP-1 receptors in the brain to increase the feeling of fullness after eating, so you naturally consume less without feeling deprived.
By changing how hungry you feel at a hormonal level, GLP-1 injections make it significantly easier to maintain a calorie deficit — without relying on willpower alone.
By improving insulin sensitivity, GLP-1 medications help regulate blood sugar alongside weight loss — making them particularly effective for patients with slower metabolic rates.
Treatment overview
You are prescribed 1 pen every 4 weeks that contains 4 doses.
Doses are to be administered by injection once weekly.
Your dosage may increase every 4 weeks as you adapt to the medication.
Weight loss rooted in science
We use evidence-based treatments with personal support to help you achieve lasting results.
Our clinical approach focuses on more than just weight loss; we support your overall wellbeing.
“Our dedicated healthcare team will assess your suitability for GLP-1 Medication by evaluating your current health status and medical history. We will then prescribe and monitor your GLP-1 dosage to ensure optimum results and safety”
"For the first time in a long time, I can see a path towards reaching my goals and feeling confident in my appearance again."
Do weight loss injections work?
Yes — and the clinical evidence is substantial. Across the four treatments available through Bliss, average weight loss in trials ranges from approximately 8% to over 20% of starting body weight. Every one of these medications has outperformed placebo by a significant margin in large-scale, randomised controlled trials.
0% Up to 20% — Average body weight loss
Tirzepatide at its highest dose achieved up to 20.9% mean body weight reduction in the SURMOUNT-1 trial.
0% Patients achieving ≥5% weight loss
65–80% of patients on tirzepatide achieved at least 5% body weight reduction in clinical trials.
0% Patients achieving ≥10% weight loss
Around 70% of patients on injectable semaglutide lost at least 10% of their body weight in the STEP trials.
Thousands of people in the UK trust Bliss
Jamie
Lost 14 stone in 18 months“That achievement sparked something in me. It made me realise how much I enjoy fitness and helping others.”
Melissa
Lost 25 pounds in 3 months“The support they provided, combined with healthier lifestyle choices, helped me achieve results that I had struggled to reach on my own.”
Glenn
Lost 3.3 stone in 3 months“While I still have goals to achieve, I’m moving in the right direction and feel more hopeful than I did before I started.”
Frequently asked questions
Are weight loss injections safe?
Yes — when prescribed by a registered clinician following a full medical assessment. All weight loss injections available through Bliss are MHRA-licensed for use in the UK and are prescription-only medicines, issued only after our clinicians confirm your eligibility, review your medical history, and identify any contraindications.
As a GPhC-registered pharmacy, Bliss dispenses only genuine, manufacturer-supplied medication through regulated UK supply chains. You should never obtain prescription weight loss injections without a valid prescription from a registered prescriber.What BMI do I need for weight loss injections?
To access prescription weight loss injections at Bliss, you generally need a BMI of 30 or above, or a BMI of 27 or above alongside at least one weight-related health condition such as type 2 diabetes, high blood pressure, high cholesterol, or obstructive sleep apnoea.
Eligibility is confirmed by your clinician during your online consultation, which also screens for any contraindications to the specific treatment.Can I get weight loss injections on the NHS?
NHS access to GLP-1 weight loss injections is currently limited. NICE guidance permits prescribing of tirzepatide and semaglutide for weight management through specialist tier 3 weight management services only — not via GPs. In most areas, referral criteria are strict and waiting lists are long.
Bliss is a private service and cannot provide NHS prescriptions. If you'd prefer not to wait, or don't qualify for NHS prescribing, an online consultation with Bliss can begin the process of a private prescription with no GP referral needed.Which weight loss injection is best?
There is no single 'best' weight loss injection — the most effective option depends on your individual health profile, circumstances, and goals.
In terms of average clinical trial outcomes, Mounjaro (tirzepatide) currently produces the highest average weight loss of any licensed injection in the UK (up to 20.9%), followed by Wegovy (approximately 14.9%). Saxenda and Nevolat (liraglutide) produce approximately 8% average weight loss.
Your Bliss clinician will recommend the most appropriate treatment for you based on your BMI, medical history, and any contraindications.What is the difference between Mounjaro and Wegovy?
Both Mounjaro and Wegovy are once-weekly prescription weight loss injections, but they work differently.
Wegovy contains semaglutide, a GLP-1 receptor agonist that mimics one gut hormone. Mounjaro contains tirzepatide, a dual GLP-1 and GIP receptor agonist that mimics two gut hormones simultaneously — a mechanism that clinical trials have shown produces greater average weight loss.
In head-to-head trial data, Mounjaro has consistently outperformed semaglutide. Both are suitable for adults with BMI 30+ (or 27+ with weight-related conditions) and both are available at Bliss.Where can I get weight loss injections in the UK?
Prescription weight loss injections must be prescribed by a registered clinician and dispensed by a regulated pharmacy — they cannot be legally obtained without a valid UK prescription.
You can access a full online consultation through Bliss: complete a health questionnaire, receive a clinician assessment, and if eligible, your prescription will be dispensed by our GPhC-registered pharmacy and delivered to your door. No GP referral or face-to-face appointment is required.
Avoid purchasing weight loss injections from unregulated online sources — the risks include counterfeit products and unlicensed medications without clinical oversight.
