Mounjaro can be injected into the abdomen (at least 5cm from the navel), the upper arm, or the outer thigh.

Rotate your injection site with each weekly dose. Avoid areas that are bruised, tender, or have broken skin.

Remove the grey base cap, press the pen firmly against your skin at a 90-degree angle until you hear a click, hold for 10 seconds — keep the pen pressed against the skin until you hear a second click, then count a further 5 seconds before removing. Check the yellow indicator confirms the dose was delivered. Dispose of the pen in a sharps bin immediately.

See the full step-by-step injection guide above.

Clinical data shows that weight typically returns after stopping Mounjaro, as the appetite-regulating effects of tirzepatide are not permanent. This is why Bliss treats Mounjaro as part of a longer-term programme — including dietary support and clinician oversight — rather than a standalone prescription.

If and when you are ready to stop, your clinician will guide a planned tapering approach and help you maintain your results through lifestyle and nutritional strategies.

There is no strict Mounjaro diet, but clinical guidance recommends a balanced, reduced-calorie diet alongside treatment for optimal results. Prioritise protein (to preserve muscle mass during weight loss), vegetables, and whole foods. Reduce ultra-processed foods and high-fat meals, which can worsen gastrointestinal side effects.

Your Bliss programme includes nutrition coaching — your clinician or support team can provide personalised dietary guidance.

You can drink alcohol on Mounjaro, but it's worth being aware of a few things. Alcohol can make nausea worse — one of the most common side effects — and can lower blood sugar, which matters if you're also taking diabetes medication. It also adds calories that can slow your progress.

Moderation is sensible; if you have concerns, speak to your Bliss clinician.

Some patients experience temporary hair shedding while taking Mounjaro. This is most likely linked to rapid weight loss — a well-recognised pattern called telogen effluvium that can occur with any effective weight loss treatment. It typically resolves on its own over time.

Worth noting: the SURMOUNT-1 trial showed slightly higher rates of hair shedding on tirzepatide versus placebo (around 5–6% vs 1%) [1], suggesting the medication itself may also play a role.

If you notice significant or persistent hair loss, let your Bliss clinician know.